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Gallstones cause problems such as pain, yellowing of your skin and the whites of your eyes (jaundice), inflammation of your pancreas (pancreatitis), and gallbladder inflammation. They occur when bile, which is normally fluid, forms stones. Gallstones commonly contain lumps of fatty (cholesterol-like) material that has solidified and hardened. They may also contain bile pigments and calcium deposits. These stones can block the bile duct, causing pain.

Surgery is the usual treatment for gallstones that are causing symptoms, but treatment with ursodeoxycholic acid may dissolve smaller stones which are made mainly of cholesterol. Ursodeoxycholic acid is a bile acid which is produced naturally by the body. It works by reducing the amount of cholesterol released by your liver and by slowly dispersing the cholesterol. This breaks up the stones.

Some ursodeoxycholic acid preparations can also help to treat primary biliary cholangitis. This is a condition that slowly damages the bile ducts in the liver, and as the disease progresses, it can damage the liver.

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Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking ursodeoxycholic acid it is important that your doctor or pharmacist knows:

  • If you have problems with the way your liver works.
  • If you have a problem with your gallbladder other than gallstones.
  • If you have a condition which affects your intestines (such as Crohn‚s disease or ulcerative colitis), or if you have had surgery on your bowel.
  • If you are pregnant, trying for a baby or breast-feeding.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines. In particular, let your doctor know if you are taking the oral contraceptive pill or hormone replacement therapy.
  • If you have ever had an allergic reaction to a medicine.

Contact your doctor immediately if any of these symptoms are experienced on a regular basis.Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

  • Diarrhea
  • Indigestion
  • Headache
  • Nausea or Vomiting
  • Back painsevere
  • Bloody and cloudy urinesevere
  • Black or tarry stools
  • Unusual bleeding or bruisingrare
  • Frequent and/or painful urinationsevere
  • Fever and coughsevererare
  • Hair lossrare
  • Swelling of eyelids, face, lips, tonguesevererare
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests, scans or X-rays from time to time.
  • It is important that you follow any dietary advice that you have been given by your doctor. Try to avoid foods that are high in calories or cholesterol.
  • You may need to take ursodeoxycholic acid for up to two years for the treatment of gallstones. Once the gallstones have dissolved, your doctor may continue your treatment for three to four months to ensure that they have completely cleared up. Treatment for primary biliary cholangitis is usually long-term unless you experience an adverse effect.
  • If you buy any medicines, check with a pharmacist that they are suitable to take with this medicine. This is particularly important if you are buying indigestion remedies. Some antacid preparations contain aluminium salts which can interfere with the way ursodeoxycholic acid works.
  • If you are using oral combined hormonal contraception (the ‚pill‚), please ask your doctor for advice. A method of contraception that contains less oestrogen may be more suitable for you.

Important Notice:- The Database is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.